Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations.
Study the latest research findings by international experts! This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate.
Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine. Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effects Cannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public.
No other book available offers this comprehensive, even-handed look at a deeply divisive subject. Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each.
Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others.
With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies.
Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis.
Developmental Neurotoxicology addresses a number of basic principles underlying the vulnerability of the developing nervous system to environmental toxicant exposure. Evidence of functional alterations, induced at levels of chemical exposure that fail to produce structural teratological alterations, indicates that the evaluation of the functional capacity of exposed animals may indeed offer a sensitive evaluation of developmental toxicity.
The contributing authors discuss the basic principles of development in structure and functional components and present information covering various methodological approaches, as well as evidence for the value of examining the developing nervous system for environmentally induced perturbations. The final chapter covers how this type of data is used to evaluate human risk potential. Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases.
The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry.
Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity.
Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology. Skip to content. Handbook of Developmental Neurotoxicology. Author : William Slikker, Jr. Handbook of Developmental Neurotoxicology Book Review:. Handbook of Developmental Toxicology.
Author : Ronald D. Handbook of Developmental Toxicology Book Review:. Handbook of Neurotoxicology. Author : Edward J. Handbook of Neurotoxicology Book Review:. The Laboratory Rat. Author : George J. The Laboratory Rat Book Review:. Environmental Health Perspectives. Environmental Health Perspectives Book Review:.
Haschek and Rousseaux s Handbook of Toxicologic Pathology. Author : Wanda M. Haschek,Colin G. Rousseaux,Matthew A.
Handbook of Toxicology. Author : Michael J. Derelanko,Carol S. Handbook of Toxicology Book Review:. Developmental and Reproductive Toxicology.
Developmental and Reproductive Toxicology Book Review:. In Vitro Neurotoxicology. Walters Lein Lantz, Sumit Sarkar, Syed F. Ali and Merle G. Paule Fisher, Xiaoxia Yang and Charles Timchalk Lantz, Syed Z. Imam, Merle G. Paule and Syed F. Ali Salisbury, R. Agans, M. Huddleston, A.
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Talpos and Merle G. Determining the validity of pre-clinical behavioral assessments for extrapolation to a clinical setting John C.
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